$50M Bitcoin Buy Signals Semler Scientific’s Deepening Crypto Commitment

Semler Scientific (NASDAQ: SMLR) has once again added to its growing bitcoin treasury, purchasing 455 BTC for $50 million—its third-largest buy since formally shifting to a bitcoin-first capital strategy last year.

Acquired over the 10-day stretch ending May 22, the latest tranche was secured at an average price of $109,801 per bitcoin. The purchase was financed through Semler’s at-the-market equity issuance program, under which the company has now raised $114.8 million by issuing just over 3 million shares since April 15.

With this acquisition, Semler’s total holdings now stand at 4,264 BTC, accumulated at a cost basis of $390 million and currently valued at more than $450 million—a notable gain reflecting the firm’s aggressive alignment with the digital asset.

The company’s BTC Yield, a metric tracking bitcoin held relative to diluted shares outstanding, has climbed to 25.8% year-to-date, cementing Semler’s role as one of the most BTC-leveraged public firms.

Despite the strategic accumulation, shares of SMLR slid 5.3% in premarket trading Friday, as bitcoin prices pulled back to $108,300 amid heightened market volatility triggered by geopolitical developments.

Semler’s continued conviction underscores the growing institutional narrative that bitcoin is more than a hedge—it’s a balance sheet backbone.